Advanced Practice Providers: Inflammatory Myopathies: From A to Z-Inflammatory Myopathies: From A to Z

Video Transcription

Video Summary

This video is a presentation titled "Inflammatory Myopathies from A to Z" given by three doctors: Dr. Justin Kwan, Dr. Shobha Bilagelar, and Dr. Tasim Musafar. The presentation discusses different aspects of inflammatory myopathies and includes the analysis of three patient cases. The first case is a 24-year-old female with weakness in her upper and lower extremities. She had a normal creatine kinase (CK) level, but elevated inflammatory markers. The patient underwent electrodiagnostic studies and a muscle biopsy, which showed periphysical atrophy and elevated aldolase. She tested positive for the MJ antibody and was diagnosed with dermatomyositis. The presentation highlights that a normal CK level is not unusual in myopathies and emphasizes the importance of comprehensive testing and considering different antibodies for accurate diagnosis. <br />The second case is a 51-year-old female with persistent and progressive proximal leg weakness. She had a history of Lyme disease, Graves' disease, and recurring sinusitis. Following extensive laboratory and imaging studies, a muscle biopsy and myositis autoantibody panel were obtained. The patient tested positive for the PL12 antibody, indicating antisynthetase syndrome. Antisynthetase syndrome is characterized by an inflammatory myopathy, interstitial lung disease, Raynaud's phenomena, mechanic's hand, and non-erosive arthritis. The presentation discusses the pathology findings of antisynthetase syndrome, including perimysial connective tissue fragmentation, necrosis of periphysicular fibers, and intranuclear actin aggregates. The importance of effective communication with neuromuscular pathologists is stressed for accurate diagnosis. The presentation concludes with a discussion of the heterogeneous nature of inflammatory myopathies and the importance of understanding the different subtypes and their multisystemic involvement. The presenters also emphasize the need for collaboration among medical specialists and effective use of clinical markers and pathological findings for accurate diagnosis and treatment. No credits were mentioned in the video.

Asset Caption

There are 2 questions in the Post Exam. Please use these questions to help test your knowledge after viewing the course. There is not a minimum score needed to pass.

Keywords

Inflammatory Myopathies

A to Z

patient cases

dermatomyositis

PL12 antibody

antisynthetase syndrome

pathology findings

neuromuscular pathologists

multisystemic involvement