Invited Review: Limb-girdle muscular dystrophies: A scoping review and overview of currently available rehab strategies-Link to Article

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The article "Limb-girdle muscular dystrophies: A scoping review and overview of currently available rehabilitation strategies" by Giorgia D'Este et al. offers a comprehensive look at current rehabilitation strategies for limb-girdle muscular dystrophies (LGMDs), a group of inherited disorders causing progressive muscle weakness. Despite the absence of a cure, the review underscores that rehabilitation can help manage symptoms, with exercise playing a central role.<br /><br />A systematic search of major databases led to the inclusion of 16 relevant studies focusing on rehabilitation approaches for various LGMD subtypes. The emphasis is placed on neuromuscular functional rehabilitation and respiratory interventions. Findings suggest that exercise must be tailored specifically to individuals, balancing the benefits of improved strength and functionality with the risks of fatigue and muscle damage. Customized muscle training, including both aerobic and low-intensity strength training, can positively enhance strength and psychological well-being. However, protocols need careful monitoring to avoid exacerbating the condition.<br /><br />Respiratory interventions are crucial, especially given that LGMDs can lead to respiratory insufficiency. The early management of such symptoms through non-invasive ventilation and respiratory muscle training can improve patients' capacity to engage in further rehabilitation exercises.<br /><br />Future direction calls for a more individualized approach, considering each LGMD subtype's unique characteristics. Integrated care systems, incorporating various therapeutic disciplines, are necessary to address both physical and psychological aspects of living with LGMD. The document recommends that future research focus on long-term outcomes of rehabilitation programs and their psychological impact, highlighting the breadth of support required for effective LGMD management.

Keywords

Limb-girdle muscular dystrophies

rehabilitation strategies

muscle weakness

neuromuscular rehabilitation

respiratory interventions

customized exercise

aerobic training

non-invasive ventilation

integrated care systems

psychological well-being