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Self-Assessment: Immune Mediated Peripheral Neurop ...
Immune Mediated Peripheral Neuropathies: Session r ...
Immune Mediated Peripheral Neuropathies: Session recording
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Video Summary
In a session on immunomediated neuropathies, experts discussed various aspects of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and its variants. CIDP is identified as a spectrum, not a single disease, characterized by inflammatory demyelination, with a prevalence of one to nine per 100,000 individuals. The session highlighted the diagnostic challenges due to the lack of specific biomarkers, leading to both over and under-diagnosis. CIDP encompasses both typical forms, with symmetric weakness and sensory loss, and atypical variants such as distal, multifocal, and motor-dominant forms, each having distinct clinical and electrodiagnostic profiles. The importance of differentiating CIDP from other neuropathies with overlapping symptoms, such as anti-MAG neuropathy and Multifocal Motor Neuropathy, was emphasized.<br /><br />The role of immune system components, such as T-cells and macrophages, was discussed in the pathological progression of CIDP. New diagnostic guidelines from the European Academy of Neurology now categorize CIDP into its typical form and variants, guiding more precise treatment and management strategies. The session also covered new advancements in therapeutic approaches, including the use of FCRN antagonists, monoclonal antibodies targeting B-cells, and complement system inhibition. <br /><br />Speakers noted the potential of these therapies for varied clinical phenotypes and the need for more personalized treatment plans based on specific disease mechanisms. They emphasized current research in biologics and the need for thoughtful consideration of therapeutic options, especially in cases refractory to traditional treatments like rituximab. This highlights an evolving understanding in the pathogenesis and management of immunomediated neuropathies.
Keywords
Chronic Inflammatory Demyelinating Polyneuropathy
cidp
immunomediated neuropathies
inflammatory demyelination
diagnostic challenges
biomarkers
typical and atypical variants
immune system
T-cells
macrophages
therapeutic approaches
FCRN antagonists
monoclonal antibodies
cidp
Chronic Inflammatory Demyelinating Polyneuropathy
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