OasisLMS

Abstract
Dysmyelinating forms of hereditary motor and sensory neuropathy (HMSN) typically exhibit uniform conduction slowing on electrophysiological studies. However, this has been challenged in the past few decades with the discovery of novel gene mutations that induce nonuniform conduction slowing resembling acquired demyelinating neuropathies. Conduction block (CB) and/ or excessive temporal dispersion (TD) are characteristic of segmental changes. Nevertheless, there is no consistent definition for CB and TD in inherited neuropathies. Pathological changes at paranodal regions or segmental demyelination might be explanatory
in some patients.

Objectives: The objectives of this activity are to recognize clinical and electrodiagnostic features of HMSNs with non-uniform slowing. Learn the pathophysiology underlying conduction block and temporal dispersion.

Hebatallah R. Rashed - no disclosures