8/11/2015-  Noah Kolb, MD, interviews Neil Simon, MBBS, BSc, FRACP, about his article on patterns of clinical and electrodiagnostic abnormalities in early ALS, published in Muscle and Nerve with Drs. Lomen-Hoerth and Kiernan. Drs. Kolb and Simon discuss the distribution of clinical and neurophysiological abnormalities in patients with early ALS. Clinical and electrodiagnostic data were collected from 150 ALS patients and analyzed based on the clinical region of onset. Findings suggest a pattern of disease spread in ALS. This study may serve to guide ongoing development of disease quantitation biomarkers and the targeting of future neuroprotective strategies. Muscle Nerve 50: 894–899, 2014