Join this Lessons From the Lab as Dr. Devon Rubin picks the amazing brains of Drs. Donald Sanders and Janice Massey on the approach to a patient with weakness. Learn what it means when a patient walks into the office sucking on hard candy as well as what tools should be used to think about and assess for an uncommon neuromuscular disorder.

11/3/2021-   Dr. Elahi Behzad interviews Dr. Michael H. Rivner on the clinical features of LRP4/agrin-antibody–positive Myasthenia Gravis.    21 minutes

7/17/2019-  Dr. Justin Willer interviews Dr. Michael Hehir on his article, Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis. A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)‐antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest thymectomy may not be efficacious in anti–muscle‐specific kinase (MuSK)‐MG. Methods: The therapeutic impact of thymectomy was evaluated from data collected for a multicenter, retrospective blinded review of rituximab in MuSK‐MG. Results: Baseline characteristics were similar between thymectomy (n = 26) and nonthymectomy (n = 29) groups, including treatment with rituximab (42% vs. 45%). At last visit, 35% of thymectomy subjects reached the primary endpoint, a Myasthenia Gravis Foundation of America (MGFA) post‐intervention status (PIS) score of minimal manifestations (MM) or better, compared with 55% of controls (P = 0.17). After controlling for age at onset of MG, rituximab, prednisone, and intravenous immunoglobulin/plasma exchange treatment, thymectomy was not associated with greater likelihood of favorable clinical outcome (odds ratio = 0.43, 95% confidence interval 0.12–1.53, P = 0.19). Discussion: Thymectomy was not associated with additional clinical improvement in this multicenter cohort of MuSK‐MG patients. Muscle Nerve 59:404–410, 2019

12/28/2012-  Paraneoplastic Neuromuscular Disorders by Drs. Lydia Sharp and Steven Vernino, interviewed by Dr. Ted Burns, Muscle Nerve. 2012 Dec;46(6):839-40. doi: 10.1002/mus.23502.

12/14/2007-  An Interview with Monique Ryan, M Med, BS, FRACP and Robert Ouvrier, MD, BS, BSc, coauthors of Autosomal-recessive and X-linked forms of hereditary motor and sensory neuropathy in childhood. Muscle Nerve 2007;36:136-143. Interviewed by Ted Burns.

11/5/2007-  An Interview with Andrew G. Engel, MD, author of The therapy of congenital myasthenic syndromes. Neurotherapeutics 2007;4:252-257. Interviewed by Elliot Dimberg, MD and Jeremy Lanford, MD. The participants in this podcast had nothing to disclose.

6/21/2007-  An interview with C. Miller Fisher, MD author of An unusual variant of acute idiopathic polyneuritis (syndrome of opthalmoplegia, ataxia and areflexia). New Engl J Med 1956;255:57-65 Interviewed by Ted Burns, MD and Robert Pascuzzi, MD. The participants in this Podcast had nothing to disclose.