Invited Review: The Notch signaling pathway in skeletal muscle health and disease-Article

Article

Pdf Summary

The Notch signaling pathway is important for skeletal muscle development and regeneration. Mutations in genes like MEGF10, POGLUT1, and JAG2, which interact with this pathway, are associated with different types of muscular dystrophy. Other genes like TRIM32, ATP2A1, JAG1, PAX7, and NOTCH2NLC also have links to the Notch pathway. Understanding these interactions could help develop therapies for muscle diseases. Compounds targeting the Notch pathway show promise in treating muscle diseases. Further research is needed to fully understand the clinical relevance and identify more related genes. Overall, the Notch pathway is crucial for skeletal muscle biology and potential therapeutic targets.

Keywords

Notch signaling pathway

skeletal muscle development

skeletal muscle regeneration

MEGF10

POGLUT1

JAG2

muscular dystrophy

TRIM32

ATP2A1

JAG1