Teachable Moment- Facilitation in LEMS-Video

Video Transcription

Video Summary

Aziz Shaybani, a neuromuscular specialist, discusses facilitation in neuromuscular medicine, a key feature of Lambert-Eaton syndrome. Exercise facilitation involves increased muscle strength or enhanced deep tendon reflexes following muscle contraction and rest, due to antibodies blocking voltage-gated calcium channels, preventing acetylcholine release. This phenomenon, demonstrated in a video, plays a vital role in diagnosing limb-specific conditions. Facilitation over 400% in one muscle indicates LEMS, with more than 100% across several muscles being significant. An optimal 10-second exercise is recommended for clinical and electrical facilitation assessment in patients with myopathy.

Keywords

neuromuscular medicine

Lambert-Eaton syndrome

exercise facilitation

voltage-gated calcium channels

myopathy assessment