11/30/2024- In this AANEM podcast, Dr. Kelly Gwathmey interviews Dr. Aziz Shaibani and Dr. Yasser Hussain, two experienced neuromuscular specialists who run successful private practice clinical research programs in Texas. They discuss the motivations for conducting clinical trials, including expanding treatment options for patients and contributing to medical advancement. The experts share valuable insights about building research infrastructure, recruiting patients, managing competing trials, and balancing clinical duties with research responsibilities. They emphasize the importance of having well-trained research coordinators, efficient databases, and proper facility space. Both physicians stress the need for more clinical trial training in medical education and encourage young physicians to enter the field, noting that while only 5% of physicians participate in clinical trials, there are over 200,000 trials currently listed in the USA, presenting significant opportunities for new researchers. 24 min.
4/30/25- This AANEM podcast features Dr. Joome Suh, a neurologist and neuromuscular specialist at Brigham and Women's Hospital, interviewed by neuromuscular fellow Dr. Nadia Khalil. They discuss HMG-CoA reductase immune-mediated necrotizing myopathy (HMGCR IMNM), a rare autoimmune muscle disease often associated with statin use. The discussion covers clinical presentation, epidemiologic considerations, histopathologic findings, and treatment approaches, with special focus on Dr. Suh’s recent research published in Muscle and Nerve with co-author Dr. Anthony Amato. Their study found that patients receiving maintenance IVIG as part of their regimen were more likely to have a normal CK at 6 months and the daily prednisone-equivalent was lower. A sub-group analysis suggested IVIG as monotherapy is effective. 13 min
5/9/2007- An Interview with Matthew Kiernan, MD, author of Uremic Neuropathy: clinical features and new pathophysiologic insights. Muscle and Nerve 2007;35:273-290 Interviewed by Ted Burns, MD and Erik Ensrud, MD.
5/15/2024 - Dr. Nadia Khalil interviews Dr. Milind Kothari and Dr. Sandra Hearn on academic practice. They define what life as a clinician educator looks like and share pearls from their own journeys for success. 28 min.
6/21/2007- An interview with C. Miller Fisher, MD author of An unusual variant of acute idiopathic polyneuritis (syndrome of opthalmoplegia, ataxia and areflexia). New Engl J Med 1956;255:57-65 Interviewed by Ted Burns, MD and Robert Pascuzzi, MD. The participants in this Podcast had nothing to disclose.
9/30/2020- Dr. Sandra Hearn interviews Dr. Darryl Sneag, Dr. Scott Wolfe, and Dr. Joseph Feinberg about their work in advancing our understanding of anterior interosseous nerve syndrome, based on their article: Sneag DB, Arányi Z, Zusstone EM, Feinberg JH, Queler SC, Nwawka OK, Lee SK, Wolfe SW. Fascicular constrictions above elbow typify anterior interosseous nerve syndrome. Muscle & Nerve. 2020 Mar;61(3):301-10. The authors describe how severe anterior interosseous nerve syndrome (AINS) reveals fascicular constrictions of the AIN fascicles within the median nerve, typically localizing proximal to the elbow. The findings support an evolving understanding that many idiopathic mononeuropathies may arise from inflammatory (rather that compressive/entrapment) etiologies. 49 minutes
11/8/2024 - In this comprehensive discussion, four prominent neuromuscular experts—Drs. Bhaskar Roy, Jeff Allen, Diana Castro, and Luis Querol—explore recent developments in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). The conversation centers on the new European Academy of Neurology and Peripheral Nerve Society guidelines, highlighting significant changes in diagnostic criteria and disease classification. The experts discuss the challenges of diagnosing CIDP, particularly in pediatric cases and variant forms, while emphasizing the importance of proper electrodiagnostic testing and the role of supportive criteria like CSF studies and MRI. They delve into the emerging field of autoimmune neuropathies and the significance of specific antibody testing. The podcast concludes with a discussion of treatment options, including traditional approaches (IVIG, corticosteroids, plasmapheresis) and newer therapies such as FcRn inhibitors and complement-targeting drugs, while also addressing the controversial role of rituximab in CIDP treatment. Throughout the discussion, the experts stress the importance of regular diagnostic reassessment and the need for more personalized treatment approaches based on patient profiles. 34 min
9/15/2024- Dr. Andrés De León interviews Drs. Simon Podnar and Gregor Omejec about their research on recovery of ulnar nerve conduction block at the elbow. 32 minutes
Have you ever encountered a patient with progressive patchy weakness in various muscles throughout the body? Have you ever performed an EMG in which the findings don’t always fit perfectly into what you were expecting? Have you ever wondered whether you even need to perform an EMG in a patient with weakness? Have you ever wondered how much fun it would be to listen to a new episode of Lessons From the Lab? Well, you have come to the right place to find some answers to these questions! Join Drs. Rubin and Narayanaswami as they ponder and discuss many clinical, electrodiagnostic, and practical approaches to an interesting patient with progressive weakness.