1/30/2025-In this AANEM podcast, Dr. Stino interviews Dr. Allen on the groundbreaking ADHERE study, published in Lancet Neurology in 2024, which investigated efgartigimod for treating Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). As the largest CIDP trial to date with 322 patients across 146 sites, it marked the first major study of a targeted biologic therapy in CIDP. The trial featured a unique two-stage design: an open-label response phase followed by a randomized controlled phase for responders. Dr. Allen explains the rationale behind targeting IgG in CIDP, despite its less clear antibody-mediated mechanism compared to myasthenia gravis. The study demonstrated a 66-70% response rate in the open-label phase, with significantly lower relapse rates compared to placebo in the randomized phase. This research represents a significant advancement in CIDP treatment options, offering a weekly subcutaneous administration that could reduce treatment burden compared to traditional therapies. 31 min.

Join in to this episode of Lessons From the Lab as Drs. Rubin and Hobson-Webb discuss a challenging case filled with many things to ponder. Is the arm finding related to the neuropathy? Are the findings indicative of dJoin in to this episode of Lessons From the Lab as Drs. Rubin and Hobson-Webb discuss a challenging case filled with many things to ponder. Is the arm finding related to the neuropathy? Are the findings indicative of demyelination? Is there conduction block? Is Dr. Rubin good at ultrasound scanning? You will be sure to learn quite a bit during this discussion!

8/31/2024-  Dr. Chilvana Patel interviews Dr. Khadilkar on the article titled "Acquired Hyperexcitable Peripheral Nerve Disorders: Clinical and Laboratory Features, Therapeutic Responses, and Long-Term Follow-Up." This study examines the clinical and laboratory characteristics of acquired hyperexcitable peripheral nerve disorders, evaluates therapeutic responses, and provides insights from long-term follow-up observations. 17 min.

Dr. Devon Rubin presents Dr. David Preston with a challenging case of a man with subacute lower extremity weakness. Enjoy the potpourri of information about anticoagulation, A waves, F waves, demyelination, ultrasound, Siri, and so much more!

Devon Rubin, MD, is joined by John Kincaid, MD, to discuss which is the most important tool in the neurologists bag, the largest wad of cotton, and interesting findings in a patient with foot numbness.